Next‐generation polymerized human hemoglobins research gets published
The Palmer lab research on use of polymerized human hemoglobins for use in hepatic bioreactor simulations gets published in Biotechnology Progress Journal.
The journal article talks about synthesis and in vitro biophysical charaterization of polymerized human hemoglobins. The synthesis and purification method improved upon previous generation products by reducing the percentage of small molecular weight polymerized species that have the potential to cause vasoconstriction and systemic hypertension. The article employed an HPLC-SEC based novel spectral deconvolution tool to determine percentage of different order polymerized species in the final product.
Finally, a single fiber of a hepatic HF bioreactor was computationally modeled with finite element methods to simulate the effects of employing synthesized product to facilitate oxygen transport.
The article can be found here: https://aiche.onlinelibrary.wiley.com/doi/full/10.1002/btpr.2958